The ability to customize your keyboard shortcuts is essential because every Artist’s workflow is different. If the software you’re using doesn’t give you the option to customize or it’s limited in its ability to customize, then consider these apps (both are free):
I have used AutoHotkey back when I was on Windows, and all I can say is that it’s a powerful scripting language for getting things done on Windows. I would say a lot more powerful than Karabiner! Examples: Detecting pixels on screen, working with files etc… At the moment I don’t know of an equivalent for Mac.
If you’re on Mac and all you want to do is customize keyboard shortcuts then Karabiner is all you need (look into AppleScript if you want to go beyond keyboard customization). It’ll take a bit of reading and once you understand the file’s format/structure you can easily customize keyboard shortcuts for ANY application.